a case of progressive rhino-orbital mucormycosis involving the brain via direct extension, retrograde perineural spreading and middle cerebral artery vasculopathy

نویسندگان

bahaadin siroos department of neurology, imam khomeini hospital, tehran university of medical sciences, tehran, ir iran

zahra sharify bahram department of neurology, imam khomeini hospital, tehran university of medical sciences, tehran, ir iran

omid ghaemi department of radiology, imam khomeini hospital, tehran university of medical sciences tehran, ir iran

seyyed mahdi zia ziabari department of emergency medicine, poursina hospital, guilan university of medical sciences, rasht, ir iran

چکیده

introduction rhino-orbito-cerebral mucormycosis is a progressive angioinvasive fungal disorder which almost always complicates immunocompromised patients. case presentation we described a case of fulminant rhino-orbito-cerebral mucormycosis in a 65-year-old woman, who presented with progressive neurological deficits due to involvement of orbital apex and the central nervous system by local invasion of the left inferior frontal lobe, retrograde perineural spreading to the brain stem and middle cerebral arteries thrombosis. discussion early diagnosis is mandatory in managing of this life-threatening disorder. urgent surgical debridement associated with antifungal agents (amphotericin with posaconazole) is the mainstay of treatment.

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عنوان ژورنال:
archives of clinical infectious diseases

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